Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study
| Autor: | Vinod Chandran, Fawnda Pellett, Cheryl F. Rosen, Sutha Shanmugarajah, Dafna D. Gladman, Shelley B. Bull, Lihi Eder |
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| Rok vydání: | 2012 |
| Předmět: |
Proband
Genetic Markers Male medicine.medical_specialty Genotype Inflammatory arthritis Immunology Population Human leukocyte antigen HLA-C Antigens General Biochemistry Genetics and Molecular Biology Linkage Disequilibrium Psoriatic arthritis Rheumatology Gene Frequency Internal medicine Psoriasis Immunology and Allergy Medicine Humans Genetic Predisposition to Disease Allele education Genotyping Genetic Association Studies Family Health education.field_of_study business.industry Histocompatibility Testing Arthritis Psoriatic medicine.disease HLA-B Antigens Population Surveillance Female business |
| Zdroj: | Annals of the rheumatic diseases. 71(8) |
| ISSN: | 1468-2060 |
| Popis: | Objective A recent population-based study identified several HLA alleles as conferring a risk for psoriatic arthritis (PsA) among patients with psoriasis. The authors aimed to confirm these results using a family-based association study. Methods PsA probands, psoriasis probands and their first-degree family members were included. All participants were evaluated for the presence of psoriasis and inflammatory arthritis. HLA-B and -C genotyping was performed. The family-based association test was used to test for differences between PsA and psoriasis patients in transmission of candidate alleles from parents to offspring. Results A total of 178 PsA and 30 psoriasis probands and 561 first degree family members were analysed. The following HLA alleles were over-transmitted to PsA compared with psoriasis: HLA-C*12 (p=0.005), HLA-B*38 (p=0.04), HLA-B*39 (p=0.03), HLA-B*27 (p=0.002). Conclusions HLA-B*27, HLA-B*38, HLA-B*39 and HLA-C*12 alleles are potential PsA-specific genetic markers among patients with psoriasis. |
| Databáze: | OpenAIRE |
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