Evolutionary changes of immunohistological characteristics of secondary lesions in pityriasis rosea
| Autor: | Hisashi Sugiura, Harumitsu Miyauchi, Masami Uehara |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Male Pathology medicine.medical_specialty Adolescent T-Lymphocytes CD4-CD8 Ratio Inducer Cells Dermatology Biology Antigens CD1 Lesion Dermis medicine Humans Pityriasis integumentary system Epidermis (botany) General Medicine medicine.disease Antigens Differentiation medicine.anatomical_structure Langerhans Cells Concomitant Pityriasis rosea Immunology Female medicine.symptom Lymphocyte subsets |
| Zdroj: | Archives of Dermatological Research. 280:405-410 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00429978 |
| Popis: | In 15 patients with pityriasis rosea, we studied the evolutionary changes of the immunohistological characteristics of the secondary lesions. Many CD1a+ cells were seen in the epidermis and dermis of early lesions. In the well-developed lesions, the number of CD1a+ cells greatly increased in the dermis. In the late lesions, CD1a+ cells in the dermis significantly decreased as compared with the well-developed lesions. Early lesions showed a moderate T-cell infiltrate. In the well-developed lesions, the dermal T-cell infiltrate was dense, and the CD4 CD8 ratio was 2.9. The late lesions had a moderate T-cell infiltrate, in which the CD4 CD8 ratio significantly decreased as compared with the well-developed lesions. Thus, the relative decrease in CD4+ helper inducer cells during lesion regression, concomitant with a decrease in number of CD1a+. Langerhans cells, is in accordance with a broader concept of increased suppressor mechanisms during healing. |
| Databáze: | OpenAIRE |
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