A multimodal approach to detect and monitor early lung disease in cystic fibrosis
| Autor: | Helene de Vicente, Silvia Bertolo, Felix Ratjen, Alex Horsley, Pedro Mondéjar-López, Òscar Asensio de la Cruz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Cystic Fibrosis Lung Clearance Index Cystic fibrosis 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Humans 030212 general & internal medicine Lung medicine.diagnostic_test business.industry Disease progression Public Health Environmental and Occupational Health food and beverages Magnetic resonance imaging Multimodal therapy respiratory system medicine.disease Lung involvement Magnetic Resonance Imaging respiratory tract diseases Respiratory Function Tests 030228 respiratory system Lung disease Airway business Tomography X-Ray Computed |
| Zdroj: | Mondéjar-lópez, P, Horsley, A, Ratjen, F, Bertolo, S, De Vicente, H & Asensio De La Cruz, Ò 2021, ' A multimodal approach to detect and monitor early lung disease in cystic fibrosis ', Expert review of respiratory medicine, pp. 1-12 . https://doi.org/10.1080/17476348.2021.1908131 |
| DOI: | 10.1080/17476348.2021.1908131 |
| Popis: | Introduction: In the early stages, lung involvement in cystic fibrosis (CF) can be silent, with disease progression occurring in the absence of clinical symptoms. Irreversible airway damage is present in the early stages of disease; however, reliable biomarkers of early damage due to inflammation and infection that are universally applicable in day-to-day patient management have yet to be identified.Areas covered: At present, the main methods of detecting and monitoring early lung disease in CF are the lung clearance index (LCI), computed tomography (CT), and magnetic resonance imaging (MRI). LCI can be used to detect patients who may require more intense monitoring, identify exacerbations, and monitor responses to new interventions. High-resolution CT detects structural alterations in the lungs of CF patients with the best resolution of current imaging techniques. MRI is a radiation-free imaging alternative that provides both morphological and functional information. The role of MRI for short-term follow-up and pulmonary exacerbations is currently being investigated.Expert opinion: The roles of LCI and MRI are expected to expand considerably over the next few years. Meanwhile, closer collaboration between pulmonology and radiology specialties is an important goal toward improving care and optimizing outcomes in young patients with CF. |
| Databáze: | OpenAIRE |
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