| Autor: |
X. Wu, C. Liyanage, M. Plan, T. Stark, T. McCubbin, R.A. Barrero, J. Batra, R. Crawford, Y. Xiao, I. Prasadam |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Osteoarthritis and Cartilage. 31:613-626 |
| ISSN: |
1063-4584 |
| Popis: |
Metabolic pathways are a series of chemical reactions by which cells take in nutrient substrates for energy and building blocks needed to maintain critical cellular processes. Details of chondrocyte metabolism and how it rewires during the progression of osteoarthritis (OA) are unknown. This research aims to identify what changes in the energy metabolic state occur in OA cartilage.Patient matched OA and non-OA cartilage specimens were harvested from total knee replacement patients. Cartilage was first collected for metabolomics, proteomics, and transcriptomics analyses to study global alterations in OA metabolism. We then determined the metabolic routes by tracking [U-OA chondrocytes showed increased basal ECAR and more lactate production compared to non-OA chondrocytes. [U-This study represents the first comprehensive comparative analysis of metabolism in OA chondrocytes and lays the groundwork for therapeutic targeting of metabolism in OA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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