Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease
| Autor: | Berenice Reed, David M. Maahs, Melissa A. Cadnapaphornchai, Robert W. Schrier, Janet K. Snell-Bergeon, Elwaleed Elhassan, Kim McFann, Amirali Masoumi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Nephrology 030232 urology & nephrology 030204 cardiovascular system & hematology Kidney urologic and male genital diseases Severity of Illness Index chemistry.chemical_compound 0302 clinical medicine cardiovascular disease kidney volume Child Ultrasonography Proteinuria Neovascularization Pathologic Cysts Vascular Endothelial Growth Factors Polycystic Kidney Autosomal Dominant Magnetic Resonance Imaging VEGF Vascular endothelial growth factor medicine.anatomical_structure Creatinine Disease Progression Female medicine.symptom Adult medicine.medical_specialty Adolescent Heart Ventricles Autosomal dominant polycystic kidney disease Urology Renal function Kidney Volume Angiopoietin-2 Young Adult 03 medical and health sciences children Internal medicine Angiopoietin-1 medicine Humans ADPKD business.industry medicine.disease Endocrinology chemistry business Kidney disease |
| Zdroj: | Kidney International. 79(1):128-134 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.2010.355 |
| Popis: | Renal cysts, pain, and hematuria are common presentations of autosomal dominant polycystic kidney disease (ADPKD) in children. Renal function, however, is typically preserved in these patients despite increased renal volume. Since angiogenesis has been implicated in promotion of renal cyst growth in ADPKD, we measured the serum level of various angiogenic factors and early renal structural changes and cardiovascular parameters in 71 patients with ADPKD, with a mean age of 16 years. Renal structure and left ventricular mass index were measured by magnetic resonance imaging or by echocardiogram. Renal function was assessed by creatinine clearance and urinary protein excretion. Serum growth factor levels were measured by enzyme-linked immunosorbent assay. Because of skewed distributions, the various parameters are reported as log(10). Serum log(10) vascular endothelial growth factor was positively correlated with renal and cardiac structure, but negatively with creatinine clearance. Serum angiopoietin 1 levels significantly correlated with structural change in both the kidney and the heart and with urinary protein. Thus, the correlation between angiogenic growth factors with both renal and cardiac disease severity is compatible with a possible role for angiogenesis in the early progression of disease in ADPKD. |
| Databáze: | OpenAIRE |
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