Relationship between cerebral perfusion on Arterial Spin Labeling (ASL) MRI with brain volumetry and cognitive performance in mild cognitive impairment and dementia due to Alzheimer's disease
| Autor: | P.G. Rajesh, Ramshekhar N. Menon, Sushama Ramachandran, Ravi Prasad Varma, Sheelakumari Raghavan, Nandini Mohanan, Chandrasekharan Kesavadas, Bejoy Thomas, Shania M. Soman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Middle temporal gyrus Precuneus Statistical parametric mapping mild cognitive impairment Internal medicine mental disorders medicine Dementia cerebral blood flow (cbf) perfusion mri RC346-429 medicine.diagnostic_test business.industry Neuropsychology Neuropsychological test medicine.disease medicine.anatomical_structure Cerebral blood flow nervous system Posterior cingulate Cardiology alzheimer's disease Original Article Neurology (clinical) Neurology. Diseases of the nervous system business pseudo-continuous arterial spin labeling (pcasl) |
| Zdroj: | Annals of Indian Academy of Neurology, Vol 24, Iss 4, Pp 559-565 (2021) Annals of Indian Academy of Neurology |
| ISSN: | 1998-3549 0972-2327 |
| Popis: | Context: Cerebral blood flow (CBF) measurement using arterial spin labelling (ASL) MRI sequences has recently emerged as a prominent tool in dementia research. Aims: To establish association between quantified regional cerebral perfusion and gray matter (GM) volumes with cognitive measures in mild cognitive impairment (MCI) and early Alzheimer's Dementia (AD), using three dimensional fast spin echo pseudo-continuous ASL MRI sequences. Settings and Design: Hospital-based cross-sectional study. Methods and Material: Three age-matched groups, i.e., 21 cognitively normal healthy controls (HC), 20 MCI and 19 early AD patients diagnosed using neuropsychological tests and who consented for multimodality 3T MRI were recruited for the study. Statistical Analysis Used: Statistical parametric mapping and regions of interest (ROI) multivariate analysis of variance was used to ascertain differences between patients and controls on MRI-volumetry and ASL. Linear regression was used to assess relationship between CBF with GM atrophy and neuropsychological test measures. Results: Compared to HC, patients with MCI and AD had significantly lower quantified perfusion in posterior cingulate and lingual gyri, over hippocampus in MCI, with no differences noted between MCI and AD. Atrophy over the middle temporal gyrus and hippocampus differentiated AD from MCI. No significant positive correlations were noted between perfusion and GM volumes in ROI with the exception of temporal neocortex. Significantly positive coefficient b-value (p < 0.01) were apparent between global cognition with CBF in precuneus, temporal neocortex and precuneus volume, with negative b-values noted between medial temporal CBF for global cognition and recall scores. Conclusions: ROI-based CBF measurements differentiated MCI and AD from HC; volumetry of medial and neocortical temporal GM separates AD from MCI. Correlations between CBF and neuropsychology are variable and require further longitudinal studies to gauge its predictive utility on cognitive trajectory in MCI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|