The evolution of IgE-mediated type I hypersensitivity and its immunological value
Autor: | Franco H. Falcone, Piers D. Mitchell, David I. Pritchard |
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Rok vydání: | 2020 |
Předmět: |
Allergy
Immunology Basophil Immunoglobulin E medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Allergen Hypersensitivity Immunology and Allergy Medicine Animals Mast Cells biology business.industry Rhinitis Allergic Seasonal Allergens medicine.disease Mast cell Basophils medicine.anatomical_structure 030228 respiratory system biology.protein Hay fever business Anaphylaxis Food Hypersensitivity 030215 immunology Type I hypersensitivity |
Zdroj: | AllergyREFERENCES. 76(4) |
ISSN: | 1398-9995 |
Popis: | The allergic phenotype manifests itself in a spectrum of troublesome to life-threatening diseases, from seasonal hay fever, through the food allergies, atopic eczema, asthma, to anaphylaxis. Allergy, that is an overreaction to allergen in hypersensitive individuals, results from the production of IgE, mast cell and basophil sensitisation and degranulation, requiring a range of medications to manage the conditions. Yet it is highly likely that allergy evolved for a purpose and that allergic diseases are accidental consequences of an insufficiently regulated immune response. This article presents a viewpoint from which to restore the immunological reputation of the allergic phenotype. We consider the evolutionary origins of potential allergens, toxins and parasites, and how they might have influenced early-mammal species in existence when IgE first developed. We conclude that the allergic phenotype has likely saved the lives of many more mammals than have ever died from allergy, so justifying the positive role of IgE in our evolution. |
Databáze: | OpenAIRE |
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