Proteomic signature of periodontal disease in pregnancy: Predictive validity for adverse outcomes
| Autor: | Linda Phi, Muniza Siddiqui, Manisha Ramchandani, Luca Giacomelli, Manwinder Lakha, Francesco Chiappelli, Raveena Kanwar |
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| Rok vydání: | 2011 |
| Předmět: |
Predictive validity
medicine.medical_specialty media_common.quotation_subject CINAHL Reproductive health and childbirth Cochrane Library Bioinformatics Low Birth Weight and Health of the Newborn Oral and gastrointestinal systematic review clinically relevant complex systematic review Infant Mortality medicine Dental/Oral and Craniofacial Disease Intensive care medicine media_common Selection bias Pediatric Pregnancy business.industry pregnancy complications Prevention proteomic signature of periodontal disease General Medicine Perinatal Period - Conditions Originating in Perinatal Period medicine.disease meta-analysis Low birth weight Systematic review Infectious Diseases Prediction Model Meta-analysis clinically relevant complex systematic review (CSCSR) pregnancy Biochemistry and Cell Biology medicine.symptom business adverse pregnancy outcome preterm |
| Zdroj: | Bioinformation, vol 5, iss 7 Bioinformation |
| Popis: | The rate of preterm birth is a public health concern worldwide because it is increasing and efforts to prevent it have failed. We report a Clinically Relevant Complex Systematic Review (CSCSR) designed to identify and evaluate the best available evidence in support of the association between periodontal status in women and pregnancy outcome of preterm low birth weight. We hypothesize that the traditional limits of research synthesis must be expanded to incorporate a translational component. As a proof-of-concept model, we propose that this CSCSR can yield greater validity of efficacy and effectiveness through supplementing its recommendations with data of the proteomic signature of periodontal disease in pregnancy, which can contribute to addressing specifically the predictive validity for adverse outcomes. For this CRCSR, systematic reviews were identified through The National Library of MedicinePubmed, The Cochrane library, CINAHL, Google Scholar, Web of Science, and the American Dental Association web library. Independent reviewers quantified the relevance and quality of this literature with R-AMSTAR. Homogeneity and inter-rater reliability testing were supplemented with acceptable sampling analysis. Research synthesis outcomes were analyzed qualitatively toward a Bayesian inference, and converge to demonstrate a definite association between maternal periodontal disease and pregnancy outcome. This CRCSR limits heterogeneity in terms of periodontal disease, outcome measure, selection bias, uncontrolled confounders and effect modifiers. Taken together, the translational CRCSR model we propose suggests that further research is advocated to explore the fundamental mechanisms underlying this association, from a molecular and proteomic perspective. |
| Databáze: | OpenAIRE |
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