Malignant lymphoma with a high content of epithelioid histiocytes (so-called Lennert's lymphoma)
| Autor: | Elsie Ollapally, Carlos D. Bedetti |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Pathology medicine.medical_specialty Histology Lymphoma Immunoglobulin light chain Pathology and Forensic Medicine Immunoenzyme Techniques Malignant lymphoma Immunoglobulin kappa-Chains medicine Humans Molecular Biology Aged B-Lymphocytes biology Histocytochemistry Histiocytes Cell Biology General Medicine Middle Aged medicine.disease Non-Hodgkin's lymphoma Microscopy Electron Lymphatic system Immunoglobulin M Immunoglobulin G biology.protein Ultrastructure Female Immunoglobulin Light Chains Anatomy Antibody Immunoglobulin Heavy Chains Epithelioid cell |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 399:255-264 |
| ISSN: | 1432-2307 0340-1227 |
| DOI: | 10.1007/bf00612943 |
| Popis: | The clinicopathological findings of four cases of an uncommon form of non-Hodgkin's lymphoma called malignant lymphoma with a high content of epithelioid histiocytes (MLHH) are described. In each case the peroxidase antiperoxidase technique was used for detecting cytoplasmic immunoglobulins (CIg) in the diagnostic lymphoid tissue. In one case (patient 1), IgG and IgM heavy chains and kappa light chain were detected in 30 to 40 percent of the atypical lymphoid cells. This result suggests that the proliferating B lymphocytes in this patient with MLHH are neoplastic rather than reactive in nature. We were unable to identify CIg in the proliferating lymphoid cells of the other three patients. Our case when coupled with others reported in the literature suggest that the morphologic features of MLHH (so-called Lennert's lymphoma) can be associated with a neoplastic proliferation of either T or B lymphocytes. The ultrastructural findings of one case are presented. |
| Databáze: | OpenAIRE |
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