Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43
| Autor: | Ya Bo Mei, Xiao-Yan Che, Ya-Di Wang, Vincent C.C. Cheng, Kwok-Yung Yuen, Li Wen Qiu, Yu Xian Pan, Zhi Yong Liao, Kun Wen, Wei Hao |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male viruses Cross Reactions medicine.disease_cause Antibodies Viral Cross-reactivity Coronavirus OC43 Human Major Articles and Brief Reports Antigen Nidovirales Coronavirus 229E Human medicine Immunology and Allergy Coronaviridae Animals Humans Human coronavirus OC43 skin and connective tissue diseases Antigens Viral Coronavirus biology fungi Antibody titer virus diseases biology.organism_classification Virology body regions Infectious Diseases Immunoglobulin M Severe acute respiratory syndrome-related coronavirus Immunoglobulin G Immunology Viruses biology.protein Female Brief Reports Antibody |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 0022-1899 |
| Popis: | Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)—associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a ⩾4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E. |
| Databáze: | OpenAIRE |
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