Molecular and Functional Characterization of Circulating Tumor Cells: From Discovery to Clinical Application

Autor: Klaus Pantel, Zahra Eslami-S, Luis Enrique Cortés-Hernández, Catherine Alix-Panabières
Přispěvatelé: Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Proto-Oncogene Proteins B-raf
Proteome
MESH: Proto-Oncogene Proteins B-raf / genetics
Receptor
ErbB-2 / genetics
Receptor
ErbB-2 / metabolism
Transcriptome
ras Proteins / genetics
Receptor
ErbB-2
Clinical Biochemistry
Programmed Cell Death 1 Receptor
MESH: Biomarkers
Tumor / genetics
Biomarkers
Tumor / metabolism
Humans
Liquid Biopsy
Neoplastic Cells
Circulating / metabolism
[SDV.CAN]Life Sciences [q-bio]/Cancer
Computational biology
Metastasis
03 medical and health sciences
0302 clinical medicine
Circulating tumor cell
Clinical information
medicine
Biomarkers
Tumor
Functional studies
Liquid biopsy
business.industry
Biochemistry (medical)
Cancer
medicine.disease
Neoplastic Cells
Circulating
3. Good health
MESH: Neoplastic Cells
Circulating / pathology
Programmed Cell Death 1 Receptor / genetics
Programmed Cell Death 1 Receptor / metabolism
Proteome / metabolism
030104 developmental biology
030220 oncology & carcinogenesis
Tissue biopsies
ras Proteins
business
Zdroj: Clinical Chemistry
Clinical Chemistry, American Association for Clinical Chemistry, 2020, 66 (1), pp.97-104. ⟨10.1373/clinchem.2019.303586⟩
ISSN: 0009-9147
1530-8561
Popis: BACKGROUNDOne of the objectives for the liquid biopsy is to become a surrogate to tissue biopsies in diagnosis of cancer as a minimally invasive method, with clinical utility in real-time follow-ups of patients. To achieve this goal, it is still necessary to achieve a better understanding of the mechanisms of cancer and the biological principles that govern its behavior, particularly with regard to circulating tumor cells (CTCs).CONTENTThe isolation, enumeration, detection, and characterization of CTCs have already proven to provide relevant clinical information about patient prognosis and treatment prediction. Moreover, CTCs can be analyzed at the genome, proteome, transcriptome, and secretome levels and can also be used for functional studies in in vitro and in vivo models. These features, taken together, have made CTCs a very valuable biosource.SUMMARYTo further advance the field and discover new clinical applications for CTCs, several studies have been performed to learn more about these cells and better understand the biology of metastasis. In this review, we describe the recent literature on the topic of liquid biopsy with particular focus on the biology of CTCs.
Databáze: OpenAIRE
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