Elevated soluble P-selectin levels are associated with an increased risk of early adverse events in patients with presumed myocardial ischemia
| Autor: | Ning Zhao, Antoinette Mangione, Anthony J. Killian, Pamela Taggart, Carol A. Terregino, Graham S. Hillis, William C. Dalsey |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Myocardial Ischemia Vascular Cell Adhesion Molecule-1 Infarction Chest pain Cohort Studies Internal medicine Troponin I medicine Creatine Kinase MB Form Humans Prospective Studies Risk factor Creatine Kinase Aged Aged 80 and over biology Vascular disease Unstable angina business.industry Middle Aged Intercellular Adhesion Molecule-1 Prognosis medicine.disease Isoenzymes P-Selectin ROC Curve Immunology biology.protein Cardiology Female Creatine kinase Emergencies medicine.symptom E-Selectin Cardiology and Cardiovascular Medicine business Cell Adhesion Molecules Biomarkers Follow-Up Studies |
| Zdroj: | American Heart Journal. 143:235-241 |
| ISSN: | 0002-8703 |
| DOI: | 10.1067/mhj.2002.120303 |
| Popis: | Background Cell adhesion molecules (CAMs) play a pivotal role in the interactions between leukocytes, platelets, and vascular endothelium. Soluble CAMs (sCAMs) are shed from cell surfaces and reflect cellular activation. Elevated levels of sCAMs have been reported in the acute coronary syndromes. We hypothesized, therefore, that sCAMs might prove of prognostic value in patients with acute chest pain presumed to be the result of myocardial ischemia. Methods One hundred twenty-six consecutive patients with chest pain, thought clinically to represent myocardial ischemia, were studied prospectively. Soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin) and P-selectin (sP-selectin) levels were assayed at presentation, as were cardiac troponin I (cTnI) and creatine kinase-MBmass (CK-MBmass). The primary study end point was the occurrence of a serious cardiac event (SCE) during the index admission or the subsequent 3 months. Results sP-selectin and cTnI levels were significantly higher among patients who had an early SCE (P =.006 and P |
| Databáze: | OpenAIRE |
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