Ceftobiprole for the treatment of infective endocarditis: A case series
| Autor: | Mariano Bernardo, Vittorio Attanasio, Giulia Palmiero, Chiara Oltolini, Daniela Francisci, Paolo Scarpellini, Antonio Carozza, Carlo Tascini, Marco Ripa, Carlo Pallotto |
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| Přispěvatelé: | Tascini, C., Attanasio, V., Ripa, M., Carozza, A., Pallotto, C., Bernardo, M., Francisci, D., Oltolini, C., Palmiero, G., Scarpellini, P. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty medicine.drug_class 030106 microbiology Immunology Ceftobiprole Cephalosporin MRSA Gram-Positive Bacteria Microbiology 03 medical and health sciences 0302 clinical medicine Daptomycin Internal medicine Infective endocarditis Immunology and Allergy Medicine Endocarditis Humans 030212 general & internal medicine Gram-Positive Bacterial Infections Aged Aged 80 and over business.industry Middle Aged medicine.disease Antimicrobial QR1-502 Cephalosporins Regimen Treatment Outcome Tolerability Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Journal of Global Antimicrobial Resistance, Vol 20, Iss, Pp 56-59 (2020) |
| ISSN: | 2213-7173 |
| Popis: | Objectives Ceftobiprole is a relatively new cephalosporin with broad-spectrum activity and good tolerability. Despite its promising characteristics, to our knowledge, only two case reports, previously published also by some of us, is available concerning its administration for the treatment of infective endocarditis. Hereby we report our experience in this field. Methods All the patients with infective endocarditis treated with ceftobiprole were enrolled. Results 12 cases of endocarditis were treated with ceftobiprole, 11/12 in combination with daptomycin and 1/12 as monotherapy. Gram-positive bacteria were isolated in 12/12 patients; 3 cases were polymicrobial. Cure rate was 83% (10/12 patients). In 9/12 (75%) cases, patients were switched to ceftobiprole following failure of previous antimicrobial regimen. In 3/3 patients in which ceftobiprole was administered because of persistently positive blood culture, bacteraemia clearance was rapidly achieved. Conclusions Ceftobiprole, especially in combination, could be a promising alternative treatment for infective endocarditis. |
| Databáze: | OpenAIRE |
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