Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation
| Autor: | Hang Lee, Seong Keun Sonn, Hye Young Han, You Han Lee, Jong Gil Park, Dae Yong Kim, In Hyuk Jung, Ji Young Yoo, Keun Ho Ryu, Se Jin Jeong, Goo Taeg Oh, So Young Lee, Bong Yong Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Apolipoprotein E
Male Clinical Biochemistry Mice Nude Tetrazoles Inflammation Pharmacology Biochemistry Proinflammatory cytokine Mice Apolipoproteins E medicine Animals Humans Molecular Biology chemistry.chemical_classification reactive oxygen species Reactive oxygen species biology Ginkgo biloba Cell adhesion molecule business.industry Plant Extracts Monocyte disease models animal Macrophages Drug Synergism biology.organism_classification Atherosclerosis cytokines Cilostazol medicine.anatomical_structure chemistry inflammation Molecular Medicine Original Article medicine.symptom business medicine.drug |
| Zdroj: | Experimental & Molecular Medicine |
| ISSN: | 2092-6413 1226-3613 |
| Popis: | In this study, the synergistic effect of 6-[4-(1-cyclohexyl- 1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H )-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis. |
| Databáze: | OpenAIRE |
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