Translational control in plant antiviral immunity
| Autor: | Anésia A. Santos, Iara P. Calil, João Paulo Machado, Elizabeth P. B. Fontes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
0301 basic medicine lcsh:QH426-470 Viral protein Viral pathogenesis viruses Plant Molecular Biology Biology medicine.disease_cause NSP-Interacting Kinase 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Viral envelope Viral life cycle Viral entry Genetics medicine Molecular Biology Translation suppression NIK EIF4G EIF4E food and beverages Translation (biology) Virology Argonaute lcsh:Genetics 030104 developmental biology recessive resistance genes chemistry 010606 plant biology & botany |
| Zdroj: | Genetics and Molecular Biology v.40 n.1 suppl.1 2017 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG Genetics and Molecular Biology, Iss 0 LOCUS Repositório Institucional da UFV Universidade Federal de Viçosa (UFV) instacron:UFV Genetics and Molecular Biology, Volume: 40, Issue: 1 Supplement 1, Pages: 292-304, Published: 13 FEB 2017 |
| Popis: | Due to the limited coding capacity of viral genomes, plant viruses depend extensively on the host cell machinery to support the viral life cycle and, thereby, interact with a large number of host proteins during infection. Within this context, as plant viruses do not harbor translation-required components, they have developed several strategies to subvert the host protein synthesis machinery to produce rapidly and efficiently the viral proteins. As a countermeasure against infection, plants have evolved defense mechanisms that impair viral infections. Among them, the host-mediated translational suppression has been characterized as an efficient mean to restrict infection. To specifically suppress translation of viral mRNAs, plants can deploy susceptible recessive resistance genes, which encode translation initiation factors from the eIF4E and eIF4G family and are required for viral mRNA translation and multiplication. Additionally, recent evidence has demonstrated that, alternatively to the cleavage of viral RNA targets, host cells can suppress viral protein translation to silence viral RNA. Finally, a novel strategy of plant antiviral defense based on suppression of host global translation, which is mediated by the transmembrane immune receptor NIK1 (nuclear shuttle protein (NSP)-Interacting Kinase1), is discussed in this review. |
| Databáze: | OpenAIRE |
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