Effects of subtotal resection of the fundus on development of intestinal metaplasia induced by X-ray irradiation in Donryu rats
| Autor: | Takahiro Yamamoto, Susumu Yoshikuni, Hiromitsu Watanabe, Hideki Yamamoto, Yasumi Ando, Masanori Katayama, Ken Kinoshita, Nobuyuki Hirano |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Metaplasia Pathology medicine.medical_specialty business.industry Intestinal metaplasia Rats Inbred Strains Subtotal Resection General Medicine Fundus (eye) Alkaline Phosphatase medicine.disease Rats Pathology and Forensic Medicine Disease Models Animal Radiation Injuries Experimental Combined treatment medicine Animals Gastric Fundus X ray irradiation Intestinal Mucosa business Precancerous Conditions |
| Zdroj: | Pathology International. 50:879-883 |
| ISSN: | 1440-1827 1320-5463 |
| Popis: | Eight-week-old male Crj:Donryu rats underwent subtotal resection of the fundus and X-ray irradiation. Six months later the animals were autopsied and examined for intestinal metaplasia. The numbers of alkaline phosphatase-positive foci with the two treatments in combination were significantly increased, compared to the operation alone and non-treatment groups. Histologically assessed intestinal metaplasia was also increased in the combined treatment group. In conclusion, subtotal resection of the fundus combined with X-ray irradiation is an effective induction protocol for intestinal metaplasia. |
| Databáze: | OpenAIRE |
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