Excision of Oral Leukoplakias by CO2 Laser on an Out-Patient Basis: A Useful Procedure for Prevention and Early Detection of Oral Carcinomas
| Autor: | Fausto Chiesa, Luigi Sala, Luigi Costa, Daniele Moglia, Maurizio Mauri, Stefano Podrecca, Salvatore Andreola, Renato Marchesini, Gaetano Bandieramonte, Cesare Bartoli, Giovanni Massara, Roberto Molinari |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Laser surgery Cancer Research medicine.medical_specialty Time Factors Biopsy medicine.medical_treatment Gingiva Early detection Malignancy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Oral carcinomas Outpatients Humans Medicine Mouth Floor Aged Hyperplasia Co2 laser business.industry Cancer Histology General Medicine Middle Aged medicine.disease Oral leukoplakia Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Mouth Neoplasms Laser Therapy Radiology Leukoplakia Oral business Precancerous Conditions Follow-Up Studies |
| Zdroj: | Tumori Journal. 72:307-312 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089168607200312 |
| Popis: | Several epidemiologic studies have shown that oral cancer develops among individuals with a prior diagnosis of an oral premalignant lesion. Canceration chance in these patients is 17 %, with the greatest rate occuring in the second year of observation. Based on this data, since 1981, 92 leucoplakias have been treated by out-patient laser surgery at the Istituto Nazionale Tumori of Milano. The therapeutic technique was laser excision to obtain a specimen for histology. Two groups were distinguished according to the diagnostic procedure. Thirtythree lesions (December 1981 to December 1982) were operated on without preliminary histologic examination, on the basis of a simple clinical diagnosis. Since January 1983 all leukoplakias have been biopsied in a systematic way and those negative for cancer treated with laser. Histology of the specimen showed 5 squamous cell carcinomas (15 %) in the group of patients who did not undergo preoperative biopsy. Postoperative histology showed malignancy in 6 of 59 (10.2 %) cases in spite of negative preoperative biopsies. Speckled and erosive leukoplakias had the highest canceration rate. Three of 11 patients with cancer were treated by knife excision or interstitial needle implantation because of margins in tumoral tissue or because they were unvaluable for injury by heat. Results have been satisfactory, only 2 of 54 followed leukoplakias and none of the cancers recurred during a 2 year follow-up. |
| Databáze: | OpenAIRE |
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