Does mean lung dose calculated after inhalation of alpha emitters actually reflect the risk of induction of malignant lung tumours?
| Autor: | P. Fritsch, Y. Oghiso, G. Monchaux, K. Guillet, J.P. Morlier, N. Dudoignon |
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| Přispěvatelé: | Laboratoire de Radiotoxicologie (LRT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), National Institute of Radiological Sciences (NIRS), Laboratoire de Cancérologie Expérimentale (LCE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay |
| Rok vydání: | 2003 |
| Předmět: |
Male
Lung Neoplasms Neoplasms Radiation-Induced aerosol [SDV]Life Sciences [q-bio] environmental exposure Poison control dose calculation cancer risk 030218 nuclear medicine & medical imaging Toxicology Rats Sprague-Dawley 0302 clinical medicine Medicine rat Uranium Ore Dust Inhalation exposure Inhalation Exposure Radiation Radiological and Ultrasound Technology Inhalation curium article radon General Medicine respiratory system particle size Alpha Particles 030220 oncology & carcinogenesis Female Lung tumours Actinoid Series Elements plutonium neptunium chemistry.chemical_element Alpha (ethology) Radon Radiation Dosage complex mixtures Risk Assessment uranium 03 medical and health sciences Administration Inhalation Animals Radiology Nuclear Medicine and imaging Rats Wistar intermethod comparison Radioisotopes nonhuman concentration (parameters) business.industry actinide Public Health Environmental and Occupational Health Dose-Response Relationship Radiation Rats Inbred F344 respiratory tract diseases Rats lung cancer chemistry concentration response Air Pollutants Radioactive incidence Particle size Nuclear medicine business |
| Zdroj: | RADIATION PROTECTION DOSIMETRY RADIATION PROTECTION DOSIMETRY, 2003, 105 (1-4), pp.149-152. ⟨10.1093/oxfordjournals.rpd.a006211⟩ |
| ISSN: | 0144-8420 |
| Popis: | A comparison of incidence of lung tumours in rats after inhalation exposure to aerosols containing alpha emitters which have different physico-chemical properties has been performed. Aerosols of radon and progeny, uranium ore dust, NpO 2 , PuO 2 or Cm 2 O 3 were considered for intercomparison with similar or different particle sizes. Dose-effect relationships for the frequency of malignant lung tumours appear linear up to a few Gy and then become infralinear at higher doses delivered to the lungs. The initial slope of the curves reflects the risk of induction of a lung tumour. The highest slopes of incidence were observed for radon and uranium ore dust (about 70 and 20% Gy -1 respectively) for which the most homogeneous alpha dose distribution to the lungs is expected. In a general trend, increasing the alpha-activity of deposited particles (higher specific activity of constituent radioisotopes or larger particle size) decreases the risk. The comparison of the reported data shows that the risk per Gy at 'low' doses' could vary over more than one order of magnitude depending on the physico-chemical properties of the aerosols. |
| Databáze: | OpenAIRE |
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