Tissue-specificity of prostate specific antigens: Comparative analysis of transcript levels in prostate and non-prostatic tissues
| Autor: | Michael Bachmann, Ana C. Cunha, Bernd Weigle, E. Peter Rieber, Andrea Kiessling |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Glutamate Carboxypeptidase II
Male PCA3 Cancer Research medicine.medical_treatment Acid Phosphatase Gene Expression TRPM Cation Channels GPI-Linked Proteins Receptors Odorant Prostate cancer Antigen Antigens Neoplasm Prostate Gene expression medicine Humans RNA Messenger Cyclic AMP Response Element-Binding Protein Membrane Glycoproteins business.industry Membrane Proteins Nuclear Proteins Prostatic Neoplasms Immunotherapy Prostate-Specific Antigen medicine.disease Neoplasm Proteins Basic-Leucine Zipper Transcription Factors medicine.anatomical_structure Real-time polymerase chain reaction Oncology Organ Specificity Antigens Surface Immunology Cancer research Protein Tyrosine Phosphatases business |
| Zdroj: | Cancer Letters. 236:229-238 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2005.05.021 |
| Popis: | Activation of immune defense mechanisms against tumor antigens appears to be a promising therapeutic option for advanced prostate cancer (PCa). Specific immunotherapy critically depends on target antigens that are selectively expressed in the tumorous and optional in the normal prostate tissue in sufficient amounts. Although several prostate antigens have been described and some have already been used in clinical trials, a detailed comparative evaluation of their tissue-specificity and expression levels is still lacking. We determined the transcript levels of eight prostate targets (PSA, PAP, PSCA, PSGR, Prostein, PSMA, AIbZIP, trp-p8) in 16 different tissues by quantitative PCR and calculated a tissue-specificity index (TSI) for each molecule. Besides a preferential expression in prostate for all targets, striking differences in the expression levels and TSI were revealed which may be important for the selection of appropriate antigens for immunotherapy of PCa. |
| Databáze: | OpenAIRE |
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