Interleukin-5 Transgenic Mice Show Enhanced Resistance to Primary Infections with Nippostrongylus brasiliensis but Not Primary Infections with Toxocara canis
| Autor: | Jim C. Parsons, Graham Mayrhofer, Trudy Zimmerman, Jenette Creaney, Ann Hallett, Leon P. Bignold, Christine M. Daly, Lindsay A. Dent |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
Transgene Immunology Helminthiasis Mice Transgenic Microbiology Mice parasitic diseases Eosinophilia Intestine Small medicine Animals Nippostrongylus Nippostrongylus brasiliensis Interleukin 5 Ovum Strongylida Infections Toxocariasis biology Toxocara canis biology.organism_classification medicine.disease Immunity Innate Infectious Diseases Mice Inbred CBA Parasitology Female medicine.symptom Fungal and Parasitic Infections Interleukin-5 |
| Popis: | In this study, interleukin-5 (IL-5) transgenic mice with lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensis and Toxocara canis . Relative to nontransgenic littermates, three lines of IL-5 transgenic mice with varying degrees of eosinophilia all displayed enhanced resistance to N. brasiliensis . Although the timing of final worm expulsion was similar in transgenic and nontransgenic hosts, intestinal worms in transgenic mice were fewer in number throughout infection, failed to increase in size over the course of the infection, and were much less fecund. In contrast, T. canis larvae were recovered in similar numbers from tissues of transgenic mice with “low” or “high” eosinophilia and from nontransgenic mice. These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils. |
| Databáze: | OpenAIRE |
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