Mammography screening reduces rates of advanced and fatal breast cancers : Results in 549,091 women
| Autor: | Laszlo Tabar, Hans Wallin, Per Sundén, Sven Törnberg, Tony Hsiu Hsi Chen, Helene Grundström, Joakim Ramos, Sherry Yueh Hsia Chiu, Lars Holmberg, Johan Ahlgren, Karin Leifland, Stephen W. Duffy, Anders Åkerlund, Håkan Jonsson, Ann Sundbom, Birgitta Epstein, Chen Yang Hsu, Yu Ching Chen, Edward Azavedo, Ewa Frodis, Leena Starck, Pál Bordás, Irma Fredriksson, Wendy Yi Ying Wu, May Mei Sheng Ku, Annika Björkgren, Stina Carlson, Peter B. Dean, Daniel Öhman, Jean Ching Yuan Fann, Amy Ming Fang Yen, Robert A. Smith, Gunilla Svane, Sam Li Sheng Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Time Factors mammography Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer fatality Cause of Death medicine Confidence Intervals Mammography Humans Mass Screening 030212 general & internal medicine skin and connective tissue diseases Early Detection of Cancer Aged Service (business) Sweden Cancer och onkologi medicine.diagnostic_test business.industry Obstetrics Incidence screening fungi Breast Disease food and beverages Original Articles Middle Aged medicine.disease mortality Oncology 030220 oncology & carcinogenesis Cancer and Oncology Original Article Female sense organs Mammography screening Disease Site Patient Participation business |
| Zdroj: | Cancer |
| Popis: | Background It is of paramount importance to evaluate the impact of participation in organized mammography service screening independently from changes in breast cancer treatment. This can be done by measuring the incidence of fatal breast cancer, which is based on the date of diagnosis and not on the date of death. Methods Among 549,091 women, covering approximately 30% of the Swedish screening‐eligible population, the authors calculated the incidence rates of 2473 breast cancers that were fatal within 10 years after diagnosis and the incidence rates of 9737 advanced breast cancers. Data regarding each breast cancer diagnosis and the cause and date of death of each breast cancer case were gathered from national Swedish registries. Tumor characteristics were collected from regional cancer centers. Aggregated data concerning invitation and participation were provided by Sectra Medical Systems AB. Incidence rates were analyzed using Poisson regression. Results Women who participated in mammography screening had a statistically significant 41% reduction in their risk of dying of breast cancer within 10 years (relative risk, 0.59; 95% CI, 0.51‐0.68 [P Substantial and significant reductions in the incidence rates of fatal breast cancer and advanced breast cancer with 10 years of follow‐up are observed in this analysis of greater than one‐half million Swedish women participating and not participating in breast cancer screening. These comparisons are contemporaneous, and thus are not influenced by changes in therapeutic regimens. |
| Databáze: | OpenAIRE |
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