Hikiamides A-C, Cyclic Pentadepsipeptides from Fusarium sp. TAMA 456
| Autor: | Atsuko Motojima, Yuri Sudoh, Yasuhiro Igarashi, Tsutomu Oikawa, Takao Fukuda, Yuki Tsuchiya, Nobuyasu Matsuura, Toru Okuda |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Fusarium
Mrna expression Pharmaceutical Science Biology Fusarium sp. TAMA 456 Polymerase Chain Reaction Analytical Chemistry Mice Depsipeptides Drug Discovery Gene expression Adipocytes Animals Luciferases Gene Nuclear Magnetic Resonance Biomolecular Chromatography High Pressure Liquid Pharmacology Reporter gene Adiponectin Base Sequence Molecular Structure Organic Chemistry biology.organism_classification Chiral column chromatography PPAR gamma Complementary and alternative medicine Biochemistry Molecular Medicine |
| Zdroj: | Journal of natural products. 78(4) |
| ISSN: | 1520-6025 |
| Popis: | Three new cyclic pentadepsipeptides, hikiamides A–C (1–3), were isolated from the culture extract of Fusarium sp. TAMA 456. The structures were determined by spectroscopic analysis using NMR and MS, and the absolute configurations were established by using Marfey’s method and chiral HPLC analysis. Hikiamides induced the differentiation of murine ST-13 preadipocytes into mature adipocytes at 2 μM and adiponectin mRNA expression (5- to 13-fold higher than control). They also induced PPAR-γ-dependent gene expression at a concentration from 0.63 to 10 μM in a gene reporter assay. |
| Databáze: | OpenAIRE |
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