Fabrication of pDMAEMA-coated silica nanoparticles and their enhanced antibacterial activity
| Autor: | Jooyoung Song, Inkyu Lee, Jyongsik Jang, Yujung Jung |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Staphylococcus aureus
Materials science Scanning electron microscope Nanoparticle Nanotechnology Microbial Sensitivity Tests law.invention Biomaterials Colloid and Surface Chemistry Microscopy Electron Transmission law Escherichia coli Fourier transform infrared spectroscopy chemistry.chemical_classification Cationic polymerization Polymer Silicon Dioxide Anti-Bacterial Agents Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nylons chemistry Chemical engineering Transmission electron microscopy Microscopy Electron Scanning Methacrylates Nanoparticles Particle size Electron microscope |
| Zdroj: | Journal of Colloid and Interface Science. 407:205-209 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2013.06.016 |
| Popis: | Thin pDMAEMA shells were formed on the surface of silica nanoparticles via vapor deposition polymerization. Scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and elemental analysis have been used to characterize the resulting pDMAEMA-coated silica nanoparticles. Electron microscopy studies reveal that the thin polymer shell is formed on the silica surface. In this work, the particle diameter can be controlled (from ~19 to ~69 nm) by varying the size of silica core. The antibacterial performance of the core-shell nanoparticles was investigated against both Gram-positive (Escherichia coli) and Gram-negative (Staphylococcus aureus) bacteria. Importantly, the nano-sized pDMAEMA particles presented antibacterial activity against both bacteria without additional quaternization due to its enlarged surface area. Additionally, the bactericidal efficiency was enhanced by reducing the particle size, because the expanded surface area of the cationic polymer nanoparticles provides more active sites that can kill the bacteria. |
| Databáze: | OpenAIRE |
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