Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12)
| Autor: | Amod, A, Buse, JB, McGuire, DK, Pieber, TR, Pop-Busui, R, Pratley, RE, Zinman, B, Hansen, MB, Jia, T, Mark, T, Poulter, NR, DEVOTE Study Group |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors type 2 diabetes mellitus Endocrinology Diabetes and Metabolism insulin analogues DEVOTE Study Group Insulin Glargine Type 2 diabetes urologic and male genital diseases Cardiovascular Kidney Risk Assessment CVOT Endocrinology & Metabolism Double-Blind Method chronic renal failure Diabetes mellitus Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents In patient Renal Insufficiency Chronic business.industry Type 2 Diabetes Mellitus 1103 Clinical Sciences Exploratory analysis Acute Kidney Injury Middle Aged medicine.disease female genital diseases and pregnancy complications diabetic kidney disease Insulin Long-Acting Treatment Outcome Diabetes Mellitus Type 2 Heart Disease Risk Factors 1116 Medical Physiology Chronic renal failure Original Article Female Kidney disorder 1115 Pharmacology and Pharmaceutical Sciences Cardiology and Cardiovascular Medicine business Cardiovascular outcomes Glomerular Filtration Rate |
| Zdroj: | Diabetes & Vascular Disease Research |
| Popis: | Aim: To investigate risk factors associated with kidney disorders in patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk. Methods: In DEVOTE, a cardiovascular outcomes trial, 7637 patients were randomised to insulin degludec (degludec) or insulin glargine 100 units/mL (glargine U100), with standard of care. In these exploratory post hoc analyses, serious adverse event reports were searched using Standardised MedDRA® Queries related to chronic kidney disease (CKD) or acute kidney injury (AKI). Baseline predictors of CKD, AKI and change in estimated glomerular filtration rate (eGFR) were identified using stepwise selection and Cox or linear regression. Results: Over 2 years, eGFR (mL/min/1.73 m2) decline was small and similar between treatments (degludec: 2.70; glargine U100: 2.92). Overall, 97 and 208 patients experienced CKD and AKI events, respectively. A history of heart failure was a risk factor for CKD (hazard ratio [HR] 1.97 [95% confidence interval [CI] 1.41; 2.75]) and AKI (HR 2.28 [95% CI 1.64; 3.17]). A history of hepatic impairment was a significant predictor of CKD (HR 3.28 [95% CI 2.12; 5.07]) and change in eGFR (estimate: −8.59 [95% CI −10.20; −7.00]). Conclusion: Our findings indicate that traditional, non-modifiable risk factors for kidney disorders apply to insulin-treated patients with T2D at high CV risk. Trial registration: NCT01959529 (ClinicalTrials.gov). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|