Relationship Between Exercise Oscillatory Ventilation Loop and Prognosis of Heart Failure
| Autor: | Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual Health Status 030204 cardiovascular system & hematology Severity of Illness Index Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Cardiopulmonary exercise test Respiratory response Cause of Death medicine Humans 030212 general & internal medicine Cardiac disorders Lung Aged Retrospective Studies Heart Failure Ejection fraction Exercise Tolerance Oscillatory ventilation business.industry Proportional hazards model General Medicine Middle Aged medicine.disease Prognosis Heart failure Cardiology Exercise Test Female Cardiology and Cardiovascular Medicine business Pulmonary Ventilation Respiratory minute volume |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 83(8) |
| ISSN: | 1347-4820 |
| Popis: | BACKGROUND The cardiopulmonary exercise test (CPX) is a tool for evaluating disease severity and limitations in activities of daily living in patients with cardiac disorders. However, few studies have evaluated the association between exercise oscillatory ventilation (EOV) severity and prognosis in heart failure (HF) patients with EOV. EOV severity can be evaluated by detecting endtidal CO2pressure (PETCO2, an indicator of the arterial partial pressure of CO2(PaCO2)) and minute ventilation, which is a reflection of the respiratory response to elevated CO2. We hypothesized that the magnitude of EOV severity can predict the severity and prognosis of cardiac disorders and aimed to validate this hypothesis.Methods and Results:In total, 2,043 patients who underwent symptom-limited maximal CPX between 2010 and 2016 were evaluated. We enrolled 70 patients who had HF with reduced ejection fraction (HFrEF) and EOV. The endpoint was cardiovascular death. During a median follow-up of 4.3 years, 34 participants died (48%). Those who died showed significantly larger EOV loop size and lower hemoglobin (Hb) levels than those who survived (17.3±7.0 cm2vs. 12.8±6.1 cm2, P |
| Databáze: | OpenAIRE |
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