Interleukin 10 gene single nucleotide polymorphisms in Polish patients with chronic hepatitis C: Analysis of association with severity of disease and treatment outcome
| Autor: | Ewelina Kałużna, Bogna Świątek-Kościelna, Jerzy Nowak, Iwona Bereszyńska, Jacek Wysocki, Dominika Barcińska, Dariusz Antosik, Danuta Januszkiewicz-Lewandowska, Jolanta Rembowska, Ewa Strauss, Iwona Mozer-Lisewska |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Genotype Hepatitis C virus Immunology Single-nucleotide polymorphism Biology medicine.disease_cause Polymorphism Single Nucleotide Polyethylene Glycols Young Adult 03 medical and health sciences chemistry.chemical_compound Liver disease Gene Frequency Pegylated interferon Interferon Ribavirin medicine Humans Immunology and Allergy Genotyping Inflammation Haplotype Interferon-alpha General Medicine Hepatitis C Chronic Middle Aged medicine.disease Fibrosis Recombinant Proteins Interleukin-10 Treatment Outcome 030104 developmental biology Liver chemistry Disease Progression Cancer research Drug Therapy Combination Female Poland medicine.drug |
| Zdroj: | Human Immunology. 78:192-200 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2016.10.015 |
| Popis: | It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nucleotide polymorphisms (SNPs) of IL-10 gene with severity of liver disease (degree of inflammation and stage of fibrosis) and outcome of pegylated interferon alpha and ribavirin combined therapy (sustained virological response (SVR) and relapse) in 196 Polish CHC patients infected with HCV genotype 1. The analysis included IL-10 promoter SNPs: -1082(A/G) rs1800896, -819(C/T) rs1800871, -592(C/A) rs1800872 and SNP in the 3' UTR of IL-10 gene: +4529(A/G) rs3024498. Genotyping was performed using PCR-RFLP and HRM analysis. It was demonstrated that the -592C allele is associated with mild hepatic inflammation. Moreover, it was found that the -819C allele might be associated with SVR and that the ACCA haplotype and intermediate IL-10 producer ACC haplotype are associated with SVR and non-relapse. It can be concluded that IL-10 SNPs are associated with severity of disease and response to therapy and may be considered as potential prognostic and predictive markers in CHC. |
| Databáze: | OpenAIRE |
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