Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response
| Autor: | Bettina Weigelin, Peter Friedl, Stephanie Alexander, Frank Winkler |
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| Rok vydání: | 2013 |
| Předmět: |
Membrane transport and intracellular motility Translational research [NCMLS 5]
Microscopy Cancer Invasion metastasis Cell Biology Biology medicine.disease Cell biology Immune system Therapy response Neoplasms Tumour stroma Cancer cell T cell subset Cancer research medicine Tumor Microenvironment Animals Humans Neoplasm Invasiveness Intravital microscopy |
| Zdroj: | Current Opinion in Cell Biology, 25, 5, pp. 659-71 Current Opinion in Cell Biology, 25, 659-71 |
| ISSN: | 1879-0410 0955-0674 |
| Popis: | Item does not contain fulltext Key steps of cancer progression and therapy response depend upon interactions between cancer cells with the reactive tumour microenvironment. Intravital microscopy enables multi-modal and multi-scale monitoring of cancer progression as a dynamic step-wise process within anatomic and functional niches provided by the microenvironment. These niches deliver cell-derived and matrix-derived signals that enable cell subsets or single cancer cells to survive, migrate, grow, undergo dormancy, and escape immune surveillance. Beyond basic research, intravital microscopy has reached preclinical application to identify mechanisms of tumour-stroma interactions and outcome. We here summarise how n-dimensional 'dynamic histopathology' of tumours by intravital microscopy shapes mechanistic insight into cell-cell and cell-tissue interactions that underlie single-cell and collective cancer invasion, metastatic seeding at distant sites, immune evasion, and therapy responses. |
| Databáze: | OpenAIRE |
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