Virucidal efficacy of saturated intermediate length straight-chain alcohols in biologically active protein solutions
| Autor: | George B Dove, Milton B. Dobkin, Michael A. Shearer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.drug_class
Ionic bonding Bioengineering Alcohol In Vitro Techniques Biology Monoclonal antibody Antiviral Agents Applied Microbiology and Biotechnology Vesicular stomatitis Indiana virus law.invention Structure-Activity Relationship chemistry.chemical_compound Straight chain law medicine Humans Neutral ph Serum Albumin Pharmacology General Immunology and Microbiology Proteins Biological activity General Medicine Hydrogen-Ion Concentration Combinatorial chemistry Solutions Immunoglobulin M chemistry Biochemistry Alcohols Viruses Recombinant DNA Hybridoma technology Biotechnology |
| Zdroj: | Biologicals. 19:177-185 |
| ISSN: | 1045-1056 |
| DOI: | 10.1016/1045-1056(91)90032-f |
| Popis: | Manufacturing processes for therapeutic products derived from recombinant DNA and hybridoma technology have required a re-assessment of the parameters traditionally applied for inactivation of endogenous viruses. Historically, time, temperature and concentration of the virucidal agent were the variables considered, whereas pH and ionic environment were restricted by physiological concerns to neutral pH and isotonic buffered solutions. Newer processes are less restrictive of pH and ionic environment, and this has permitted exploration of a wider range of virucidal agents and conditions. Intermediate length straight-chain alcohols are highly virucidal at low pH, with diminished activity at higher pH. Decreased activity was demonstrated by derivatives of the alcohols depending on the position of the hydroxyl group. Applications to proteins include monoclonal antibodies. |
| Databáze: | OpenAIRE |
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