Immune response biomarkers in human and veterinary research
Autor: | Alba Llibre, Darragh Duffy |
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Přispěvatelé: | Immunobiologie des Cellules dendritiques, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Veterinary medicine Immunology Disease Biology Microbiology Sensitivity and Specificity Protein detection Article 03 medical and health sciences 0302 clinical medicine Immune system Immunology and Allergy Disease biomarker Animals Humans Tuberculosis MESH: Animals MESH: Tuberculosis Biomarker discovery Type I interferon Cytokine 030203 arthritis & rheumatology MESH: Cytokines High prevalence MESH: Humans General Veterinary Interferon-alpha General Medicine MESH: Sensitivity and Specificity 3. Good health Clinical Practice Chemokine CXCL10 030104 developmental biology Infectious Diseases One Health Chemokine MESH: Biomarkers Cytokines [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Interferon-alpha MESH: Chemokine CXCL10 Biomarkers |
Zdroj: | Comparative Immunology, Microbiology and Infectious Diseases Comparative Immunology, Microbiology and Infectious Diseases, 2018, 59, pp.57-62. ⟨10.1016/j.cimid.2018.09.008⟩ Comparative Immunology, Microbiology and Infectious Diseases, Elsevier, 2018, 59, pp.57-62. ⟨10.1016/j.cimid.2018.09.008⟩ |
ISSN: | 0147-9571 |
Popis: | International audience; Biomarkers are increasingly utilised in biological research and clinical practice for diagnosis of disease, monitoring of therapeutic prognosis, or as end points in clinical studies. Cytokines are small molecules that orchestrate immune responses and as such have great potential as biomarkers for both human and veterinary fields. Given the ease of sampling in the blood, and their high prevalence in clinical applications we will focus on protein detection as an area for biomarker discovery. This is facilitated by new technological developments such as digital ELISA that have led to significant increases in sensitivity. Two highly relevant examples include type I interferons, namely IFNα, that is now directly quantifiable by digital ELISA from biological samples. The application of this approach to the study of the unique bat interferon response may reveal novel findings with applications in both human and veterinary research. As a second example we will describe the use of CXCL10 as a disease biomarker in Tuberculosis, highlighting findings from human and mouse studies that should be considered in veterinary research. In summary, we describe how cytokines may be applied as novel biomarkers and illustrate two key examples where human and veterinary research may complement each other in line with the One Health objectives. |
Databáze: | OpenAIRE |
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