The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs
Autor: | Peter A. Eden, Derry C. Roopenian, Nadja Jung, Gregory J. Christianson, Clark L. Anderson, Thomas J. Sproule, Aaron C. Brown, Lia Avanessian, Shreeram Akilesh, Eun Young Choi, Daniel J. Shaffer, Stefka B. Petkova |
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Rok vydání: | 2003 |
Předmět: |
Male
Immunoconjugates CD40 Ligand Immunology Mice Transgenic Receptors Fc Abatacept Mice Neonatal Fc receptor In vivo MHC class I medicine Animals Homeostasis Humans Immunology and Allergy Receptor Crosses Genetic Autoimmune disease Immunity Cellular biology Catabolism Immune Sera Histocompatibility Antigens Class I Receptors IgG medicine.disease Mice Inbred C57BL Protein Transport Animals Newborn Immunoglobulin G Humoral immunity biology.protein Female Immunosuppressive Agents Injections Intraperitoneal Half-Life Transcription Factors |
Zdroj: | The Journal of Immunology. 170:3528-3533 |
ISSN: | 1550-6606 0022-1767 |
DOI: | 10.4049/jimmunol.170.7.3528 |
Popis: | Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t1/2 compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions. To understand the phenotypes imposed by FcRn, we produced and analyzed mice with a defective FcRn gene. The results provide direct evidence that perinatal IgG transport and protection of IgG from catabolism are mediated by FcRn, and that the latter function is key to IgG homeostasis, essential for generating a potent IgG response to foreign Ags, and the basis of enhanced efficacy of Fc-IgG-based therapeutics. FcRn is therefore a promising therapeutic target for enhancing protective humoral immunity, treating autoimmune disease, and improving drug efficacy. |
Databáze: | OpenAIRE |
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