Figure S4 from Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Autor: Pasi A. Jänne, Nathanael S. Gray, Michael J. Eck, Kwok-Kin Wong, Suzanne E. Dahlberg, Annan Yang, Thomas W. Gero, Bo Hee Shin, David E. Heppner, Michael D. Cameron, Stephen Wang, Man Xu, Dries J.H. De Clercq, Mierzhati Mushajiang, Eunyoung Park, Ting Chen, Jaebong Jang, Ciric To
Rok vydání: 2023
DOI: 10.1158/2159-8290.22532740.v1
Popis: Not all tyrosine kinase inhibitors (TKIs) can enhance or bind at the same time as an allosteric inhibitor (AI) and co-binding of TKIs and AIs do not necessarily translate into increased drug potency.
Databáze: OpenAIRE