ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection
| Autor: | Sougata Niyogi, Parinita Majumdar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Chemokine Mutation rate Leucine zipper Epidemiology ORF3a 030106 microbiology Pneumonia Viral Biology medicine.disease_cause Epitope Viroporin Proteins 03 medical and health sciences Betacoronavirus Mutation Rate medicine Humans Viral Regulatory and Accessory Proteins Amino Acid Sequence skin and connective tissue diseases Pandemics Coronavirus Immune Evasion Genetics Mutation Original Paper SARS-CoV-2 Mortality rate COVID-19 medicine.disease mortality 030104 developmental biology Infectious Diseases biology.protein Middle East respiratory syndrome Cytokines Coronavirus Infections Signal Transduction |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268820002599 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently caused acute respiratory distress syndrome affecting more than 200 countries with varied mortality rate. Successive genetic variants of SARS-CoV-2 become evident across the globe immediately after its complete genome sequencing. Here, we found a decent association of SARS-CoV-2 ORF3a mutation with higher mortality rate. Extensive in silico studies revealed several amino acid changes in ORF3a protein which ultimately leads to diverse structural modifications like B cell epitope loss, gain/loss of phosphorylation site and loss of leucine zipper motif. We could further relate these changes to the enhanced antigenic diversity of SARS-CoV-2. Through protein−protein network analysis and functional annotation studies, we obtained a close federation of ORF3a protein with host immune response via divergent signal transduction pathways including JAK-STAT, chemokine and cytokine-related pathways. Our data not only unveil the fairly appreciable association of ORF3a mutation with higher mortality rate, but also suggest a potential mechanistic insight towards the immunopathogenic manifestation of SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|