Serum neuron specific enolase could predict subclinical brain damage and the subsequent occurrence of brain related vascular events during follow up in essential hypertension
| Autor: | Alina González-Quevedo, Zenaida Hernández-Díaz, Rosaralis Santiesteban Freixas, Sergio González-García, Isabel Fernández-Almirall, Marisol Peña-Sánchez, Luis Quevedo Sotolongo, Otman Fernández Concepción, Benjamín Márquez Rosales, María Caridad Menéndez-Sainz, Rebeca Fernández-Carriera |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Brain damage 030204 cardiovascular system & hematology Essential hypertension Asymptomatic 03 medical and health sciences Young Adult 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Vascular headache Longitudinal Studies Stroke Subclinical infection Aged Aged 80 and over business.industry Middle Aged medicine.disease Hyperintensity Blood pressure Cross-Sectional Studies Neurology Brain Injuries Phosphopyruvate Hydratase Hypertension Cardiology Female Neurology (clinical) medicine.symptom Essential Hypertension business 030217 neurology & neurosurgery Biomarkers Follow-Up Studies |
| Zdroj: | Journal of the neurological sciences. 363 |
| ISSN: | 1878-5883 |
| Popis: | The object of this work was to explore if blood based biomarkers of brain damage could predict subclinical brain lesions and clinical outcome during follow-up in asymptomatic hypertensive patients. This was a cross-sectional study including 101 patients with essential hypertension and no clinical evidence of neurological disease and 53 healthy controls, followed by a longitudinal study of 62 hypertensive patients for an average of 33 months. Serum concentrations of two brain specific proteins (S100B and neuron specific enolase - NSE) were determined at inclusion. Fundoscopic exploration, brain MRI and echocardiographic studies were also performed. Clinical outcome at follow-up was registered: transient ischemic attack (TIA), stroke, vascular headache or migraine, cardiovascular events and death. Higher serum NSE and S100B concentrations were observed in hypertensive patients; and multiple regression analysis revealed independent associations of clinical variables and more severe white matter lesions only with NSE concentration. A panel combining two clinical variables (blood pressure>140/90 and years of hypertension>10) and serum NSE>13 μg/L predicted more severe white matter lesions with 80% sensitivity and 94.4% specificity. Higher NSE levels at inclusion were associated not only with the occurrence of vascular events related with the CNS (stroke, TIA and vascular headache), but also with an earlier presentation of these events during the follow-up period. Serum NSE concentration could be a useful biomarker to predict subclinical brain damage and future vascular events related with the CNS in hypertension. Blood based biomarkers could aid in filtering hypertensive patients with a higher risk of cerebrovascular disease for brain MRI scanning. |
| Databáze: | OpenAIRE |
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