SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis
| Autor: | Tadaaki Kirita, Hiroyuki Shimomura, Miyako Kurihara-Shimomura, Tomonori Sasahira |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Angiogenesis 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Serpin E2 Gene expression Humans Medicine Lymphangiogenesis Tumor marker business.industry Microarray analysis techniques Endothelial Cells Cancer Hematology General Medicine Prognosis medicine.disease stomatognathic diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Immunohistochemistry Mouth Neoplasms Surgery business Immunostaining |
| Zdroj: | International Journal of Clinical Oncology. 26:1831-1839 |
| ISSN: | 1437-7772 1341-9625 |
| DOI: | 10.1007/s10147-021-01970-4 |
| Popis: | LEM domain containing 1 (LEMD1) is a novel factor involved in the development of oral squamous cell carcinoma (OSCC). We previously performed a microarray analysis and found that serpin peptidase inhibitor, clade E, member 2 (SERPINE2) is an LEMD1-related signal. SERPINE2 is an extracellular serine proteinase inhibitor with secretory capacity. Although SERPINE2 displays tumor-promoting properties in many cancers, some reports indicate that SRPINE2 also has a tumor-suppressing function. Therefore, there are many unclear points about its role in cancer. In this study, we investigated SERPINE2 expression in OSCC. The gene expression and secretion levels of SERPINE2 were examined in 42 frozen specimens of OSCC, and SERPINE2 immunostaining was investigated in 167 cases of OSCC. Furthermore, the effect of SERPINE2 on angiogenesis and lymphangiogenesis was analyzed using OSCC cells and endothelial cells. In the frozen specimens, the gene expression (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink