Significant linkage for Tourette syndrome in a large French Canadian family
| Autor: | Claudia Émond, Jurg Ott, Chantal Mérette, Chantal Caron, Marc-André Roy, Michel Maziade, Luc Bissonnette, Anne Potvin, Andrée Brassard, Hélène Bouvier, François Rousseau |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Genetic Markers Male Linkage disequilibrium Obsessive-Compulsive Disorder Genetic Linkage Population Penetrance Biology Tourette syndrome Genetic determinism Linkage Disequilibrium Gene Frequency Genetic linkage Report medicine Genetics Humans Genetics(clinical) Genetic Predisposition to Disease Age of Onset education Child Allele frequency Genetics (clinical) Genes Dominant education.field_of_study Chromosomes Human Pair 13 Models Genetic Chromosomes Human Pair 11 Quebec Chromosome Mapping Middle Aged medicine.disease Twin study Pedigree Haplotypes Genetic marker Tic Disorders Female Lod Score Tourette Syndrome |
| Zdroj: | American journal of human genetics. 67(4) |
| ISSN: | 0002-9297 |
| Popis: | Family and twin studies provide strong evidence that genetic factors are involved in the transmission of Gilles de la Tourette syndrome (TS) and related psychiatric disorders. To detect the underlying susceptibility gene(s) for TS, we performed linkage analysis in one large French Canadian family (127 members) from the Charlevoix region, in which 20 family members were definitely affected by TS and 20 others showed related tic disorders. Using model-based linkage analysis, we observed a LOD score of 3.24 on chromosome 11 (11q23). This result was obtained in a multipoint approach involving marker D11S1377, the marker for which significant linkage disequilibrium with TS recently has been detected in an Afrikaner population. Altogether, 25 markers were studied, and, for level of significance, we derived a criterion that took into account the multiple testing arising from the use of three phenotype definitions and three modes of inheritance, a procedure that yielded a LOD score of 3.18. Hence, even after adjustment for multiple testing, the present study shows statistically significant evidence for genetic linkage with TS. |
| Databáze: | OpenAIRE |
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