Ultrasonically nebulized distilled water prevents exogenous histamine hyperreactivity in Toxocara canis-infected mice
| Autor: | Anderson Sá-Nunes, Constance Oliver, M. Dias Baruffi, Lúcia Helena Faccioli, Maria Célia Jamur, Alexandra Ivo de Medeiros, R. M. F. Bolzoni |
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| Rok vydání: | 2005 |
| Předmět: |
Serotonin
Allergy Immunology Pharmacology toxicology Mice chemistry.chemical_compound parasitic diseases Hypersensitivity medicine Animals Ultrasonics Mast Cells Anaphylaxis Lung Pharmacology Mice Inbred BALB C Toxocariasis biology Inhalation Nebulizers and Vaporizers Toxocara canis Water biology.organism_classification medicine.disease Kinetics chemistry Distilled water Nematode infection Female Histamine |
| Zdroj: | Inflammation Research. 54:243-248 |
| ISSN: | 1420-908X 1023-3830 |
| DOI: | 10.1007/s00011-005-1347-8 |
| Popis: | This study examines the effect of ultrasonically nebulized distilled water inhalation on the systemic histamine hyperreactivity of Toxocara canis-infected mice.Uninfected and T. canis-infected mice received an intravenous sublethal dose of histamine and lethality rates were documented. At 24 days post infection, infected mice received ultrasonically nebulized distilled water inhalation for 1 h. Twenty-four hours later histamine levels were determined in bronchoalveolar lavage fluid as well as histamine lethality and toluidine blue-stained mast cell number in the lung.T. canis-infected mice showed increased lethality after exposure to histamine in comparison to uninfected mice. Ultrasonically nebulized distilled water inhalation prevented histamine-induced lethality and reduced toluidine blue-stained mast cell numbers in the lung.The correlation between decreases in stained mast cells in the lung after ultrasonically nebulized distilled water inhalation and inhibition of histamine-induced lethality in these animals suggests participation of mast cells in the phenomenon and could be helpful in understanding the mechanisms of hyperreactivity during helminth parasite infections. |
| Databáze: | OpenAIRE |
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