SELF-ASSEMBLED AMPHIPHILIC HYALURONIC ACID GRAFT COPOLYMERS FOR TARGETED RELEASE OF ANTITUMORAL DRUG
| Autor: | Giovanna Pitarresi, Antonella Albanese, Calogero Fiorica, Pasquale Picone, Fabio Salvatore Palumbo, Gaetano Giammona |
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| Přispěvatelé: | PITARRESI, G, PALUMBO, FS, ALBANESE, A, FIORICA, C, PICONE, P, GIAMMONA, G |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Magnetic Resonance Spectroscopy
SELF ASSEMBLING HYALURONIC ACID DRUG RELEASE Polymers Molecular Sequence Data Pharmaceutical Science Antineoplastic Agents macromolecular substances Micelle Cell Line chemistry.chemical_compound Mice Drug Delivery Systems Polylactic acid Cell Line Tumor Hyaluronic acid PEG ratio Amphiphile Copolymer Organic chemistry Animals Humans Hyaluronic Acid Micelles Drug Carriers Chemistry technology industry and agriculture Microscopy Electron Carbohydrate Sequence Microscopy Fluorescence Settore CHIM/09 - Farmaceutico Tecnologico Applicativo Biophysics Pyrene Drug carrier |
| Popis: | Polymeric micelles obtained by self-assembling of amphiphilic hyaluronic acid (HA) graft copolymers have been prepared and characterized. In particular, hyaluronic acid (HA) has been grafted to polylactic acid (PLA) and polyethylenglycol chains (PEG), then the copolymers able to form micelles in aqueous medium have been chosen to entrap the antitumoral drug Doxorubicin. The critical aggregation concentration of HA-g-PLA or HA-g-PLA-g-PEG micelles has been determined by using pyrene as a fluorescent probe, whereas their shape and size have been evaluated by light scattering measurements, scanning and transmission electron microscopies. The selective cytotoxicity of drug loaded micelles toward the CD-44 over-expressing HCT-116 cells compared to receptor deficient human derm fibroblasts has been demonstrated. Pegylated micelles showed better stability and drug loading capacity and they were able to escape from macrophage phagocytosis. |
| Databáze: | OpenAIRE |
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