BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase
| Autor: | Masaaki Hayashi, Young Yang, Ta Hsiang Chao, Charles C. King, Jiing Dwan Lee, Jeng Fan Lo, Richard I. Tapping |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_treatment
Protein Serine-Threonine Kinases Mitogen-activated protein kinase kinase Biochemistry Immediate-Early Proteins medicine Integrin-linked kinase Phosphorylation Protein kinase A Molecular Biology Mitogen-Activated Protein Kinase 7 Epidermal Growth Factor biology MAP kinase kinase kinase Cell growth Chemistry Growth factor Cyclin-dependent kinase 2 Nuclear Proteins Cell Biology Cell biology Enzyme Activation biology.protein Cancer research Mitogen-Activated Protein Kinases Cell Division Platelet-derived growth factor receptor |
| Zdroj: | Journal of Biological Chemistry. 276:8631-8634 |
| ISSN: | 0021-9258 |
| Popis: | Activation of the mammalian mitogen-activated protein kinase known as BMK1 is required for growth factor-induced cell proliferation. To understand the mechanism by which BMK1 mediates this cellular response, this kinase was used as bait in a yeast two-hybrid-based library screening. Here, we report the identification of serum and glucocorticoid-inducible kinase (SGK) as a cellular protein that physically interacts with BMK1. During growth factor-induced cell stimulation, BMK1 activates SGK by phosphorylation at serine 78. This BMK1-mediated phosphorylation event is necessary for the activation of SGK and, more importantly, for cell proliferation induced by growth factors. |
| Databáze: | OpenAIRE |
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