Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
| Autor: | Isabel Mejia, Begoña Díaz, Kathryn T. Chen, Sandhya Bodapati |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Tumor microenvironment
Stromal cell endocrine system diseases tumor stroma Medicine (miscellaneous) Cancer PDAC clinical trial Review Biology medicine.disease cell invasion General Biochemistry Genetics and Molecular Biology digestive system diseases Stroma Invadopodia Parenchyma medicine Cancer research Adenocarcinoma tumor microenvironment Cancer vaccine cancer vaccine invadopodia |
| Zdroj: | Biomedicines |
| ISSN: | 2227-9059 |
| Popis: | Pancreatic adenocarcinoma (PDAC) originates in the glandular compartment of the exocrine pancreas. Histologically, PDAC tumors are characterized by a parenchyma that is embedded in a particularly prominent stromal component or desmoplastic stroma. The unique characteristics of the desmoplastic stroma shape the microenvironment of PDAC and modulate the reciprocal interactions between cancer and stromal cells in ways that have profound effects in the pathophysiology and treatment of this disease. Here, we review some of the most recent findings regarding the regulation of PDAC cell invasion by the unique microenvironment of this tumor, and how new knowledge is being translated into novel therapeutic approaches. |
| Databáze: | OpenAIRE |
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