Structural abnormalities in schizophrenia: further evidence on the key role of the anterior cingulate cortex
Autor: | Benedikt L. Amann, Pauline Delaveau, Pilar Salgado-Pineda, Eric Fakra, Olivier Blin, Ramon Landin-Romero |
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Rok vydání: | 2013 |
Předmět: |
Adult
Male Neuroimaging Corpus callosum Gyrus Cinguli White matter Young Adult medicine Humans Gray Matter Prefrontal cortex Biological Psychiatry Anterior cingulate cortex business.industry Fornix Brain Limbic lobe Anatomy Middle Aged Magnetic Resonance Imaging White Matter Psychiatry and Mental health Emotional lateralization Neuropsychology and Physiological Psychology medicine.anatomical_structure Posterior cingulate Case-Control Studies Schizophrenia Female Atrophy business |
Zdroj: | Neuropsychobiology. 69(1) |
ISSN: | 1423-0224 |
Popis: | Objective: The present study examined whole-brain structural abnormalities in schizophrenia, with a special focus on the anterior and posterior cingulate cortex (ACC, PCC) as this is an understudied issue in schizophrenia. Method: Whole-brain voxel-based morphometry analyses of gray matter (GM) and white matter (WM) were performed to detect volumetric differences between 14 patients with schizophrenia and 14 healthy controls matched for age, sex, educational level and parents' educational level. We examined within-group GM and WM correlations and completed the analysis with measurements of sulci in medial cortical areas. Results: Compared with the healthy controls, the schizophrenic patients showed significant decreases in GM volumes in the ACC and PCC, and in neighboring WM regions such as the corpus callosum and the fimbriae of the fornix. Moreover, the patient group also displayed a negative correlation between volumes of GM and WM in the ACC. Finally, the patients showed significantly reduced volumes in the right cingulate sulci and left inferior frontal sulci. Conclusion: Our results replicate typical brain-structural abnormalities with new findings in the medial prefrontal cortex, suggested to be a key region in this disorder. |
Databáze: | OpenAIRE |
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