Blood urea in preterm infants on routine parenteral nutrition: A multiple linear regression analysis
| Autor: | Rita D'Ascenzo, Virgilio P. Carnielli, Luca Antognoli, Maria Paola Bellagamba, Paola Cogo, Chiara Monachesi, Chiara Biagetti, Ilaria Giretti, Ilaria Burattini, Paolo Marchionni, Alessio Correani |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Birth weight Physiology Gestational Age 030209 endocrinology & metabolism Critical Care and Intensive Care Medicine Eating 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.artery Blood urea Birth Weight Humans Urea Medicine Amino Acids Infant Nutritional Physiological Phenomena Ductus Arteriosus Patent Respiratory Distress Syndrome Newborn 030109 nutrition & dietetics Nutrition and Dietetics Respiratory distress business.industry Weight change Infant Newborn Gestational age Preterm infants Umbilical artery medicine.disease Parenteral nutrition Amino acid chemistry Creatinine Infant Small for Gestational Age Multivariate Analysis Linear Models Small for gestational age Female business Infant Premature |
| Popis: | Summary Background Blood urea is considered a marker of amino acid utilization in preterm infants on routine parenteral nutrition. However, the association between blood urea and intravenous amino acid intake remains debated. Aims To evaluate the association between blood urea and both nutrition and clinical data, in a large cohort of preterm infants. Methods Consecutively admitted preterm infants with a gestational age of less than 32 weeks and a birth weight lower than 1250 g on routine parenteral nutrition from the first hour of life were studied. Clinical and nutrition data collected hourly during the hospitalization were used in multiple linear regression analysis. Results We studied 674 patients and 1863 blood urea determinations. Blood urea concentration was positively associated with blood creatinine concentration, intravenous amino acid intake, patent ductus arteriosus and respiratory distress syndrome, and negatively associated with intravenous non-protein energy intakes, daily weight change, gestational age, being small for gestational age, antenatal steroids therapy and reverse flow in the umbilical artery (p Conclusions From a nutrition perspective, in our large cohort of small preterm infants blood urea was positively correlated with intravenous amino acid intake and negatively correlated with intravenous non-protein energy intake. This is in line with current knowledge in human physiology and suggest that a reduction of intravenous amino acid intake based on blood urea concentrations was justified. |
| Databáze: | OpenAIRE |
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