The significance of neutrophil/lymphocyte ratio as a possible marker of underlying papillary microcarcinomas in thyroidal goiters: a pilot study
| Autor: | Charalampos Seretis, George Dimitrakopoulos, Fotios Seretis, Georgios Gemenetzis, Emmanuel Lagoudianakis, Stavros Gourgiotis |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Prognostic factor Pathology Neutrophils Lymphocyte Papillary Thyroid Microcarcinoma Pilot Projects Gastroenterology Internal medicine Biomarkers Tumor medicine Humans In patient Lymphocytes Thyroid Neoplasms Thyroid cancer Aged Retrospective Studies Incidental Findings Goiter business.industry fungi Retrospective cohort study General Medicine Middle Aged medicine.disease Carcinoma Papillary medicine.anatomical_structure Case-Control Studies Preoperative Period Thyroidectomy Biomarker (medicine) Female Surgery business |
| Zdroj: | The American Journal of Surgery. 205:691-696 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2012.08.006 |
| Popis: | Background Preoperatively elevated neutrophil/lymphocyte ratio (NLR) is a negative prognostic factor of survival in various types of cancers. A retrospective study was conducted to examine if preoperative elevation of NLR is associated with higher risk for incidental papillary thyroid microcarcinoma (PTMC). Methods The study sample consisted of 26 patients with benign goiters, 31 patients with incidental PTMC, 26 patients preoperatively diagnosed with thyroid cancer, and 26 healthy controls. NLRs were compared regarding thyroidal pathology. Results The mean preoperative NLR was significantly elevated in patients with PTMC and thyroid cancer. In addition, the third and fourth quartiles of NLR included only patients with either PTMC or thyroid cancer. No significant differences in NLR occurred between patients with multifocal and unifocal PTMC. Conclusions NLRs were significantly elevated in patients with incidental PTMC and thyroid cancer. The findings of this pilot study indicate that NLR should be considered an easily accessible biomarker for detecting incidental PTCM; nevertheless, further studies are required to confirm these preliminary results. |
| Databáze: | OpenAIRE |
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