Expert Opinion on Management of Intraocular Inflammation, Retinal Vasculitis, and Vascular Occlusion after Brolucizumab Treatment
| Autor: | András Seres, Mayur R. Joshi, Richard Gale, Michael A Singer, David J. Tanzer, Nicolas Feltgen, Bahram Bodaghi, Caroline R. Baumal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Fundus Oculi Retinal Artery Occlusion Visual Acuity Physical examination Angiogenesis Inhibitors Antibodies Monoclonal Humanized Vascular occlusion Uveitis 03 medical and health sciences 0302 clinical medicine Ophthalmology Intervention (counseling) Retinal Vein Occlusion medicine Humans Fluorescein Angiography Intensive care medicine Expert Testimony 030304 developmental biology Retinal Vascular Occlusion Inflammation Retinal Vasculitis 0303 health sciences medicine.diagnostic_test business.industry Retinal vasculitis Macular degeneration medicine.disease Fluorescein angiography Critical appraisal Intravitreal Injections 030221 ophthalmology & optometry medicine.symptom business |
| Zdroj: | Ophthalmology. Retina. 5(6) |
| ISSN: | 2468-6530 |
| Popis: | Purpose Recent reports have described a spectrum of uncommon findings of intraocular inflammation (IOI), retinal vasculitis, or retinal vascular occlusion in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal injection (IVI) of brolucizumab. We present guidance on the clinical presentation of this spectrum and propose recommendations for management of these events. Design PubMed literature review and expert opinion panel. Participants A working group of international medical experts and Novartis medical personnel. Methods The working group deliberated on the clinical presentations and used a 3-pronged approach to develop management recommendations based on (1) critical appraisal of scientific literature; (2) clinical insights from the HAWK and HARRIER trials, postmarketing reports, and assessments from an independent Safety Review Committee (SRC); and (3) their clinical experience. Main Outcome Measures Management recommendations for a spectrum of ocular inflammatory events after treatment with brolucizumab or other anti–vascular endothelial growth factors (VEGFs). Results Based on insights gained from the available information and the expertise of the contributors, recommendations were proposed for ocular examinations, imaging modalities, and treatment strategies for management of this spectrum of events. Patients should be educated to promptly report any relevant or persistent symptoms after IVI to facilitate timely intervention. Patients diagnosed with IOI should be evaluated for concomitant retinal vasculitis or retinal vascular occlusive events. Clinical examination can be augmented with multimodal imaging techniques, including widefield imaging, fluorescein angiography (with peripheral sweeps), and OCT. Once confirmed, the ongoing brolucizumab treatment should be suspended and intensive treatment with potent corticosteroids (topical, subtenon, intravitreal, or systemic) is recommended, which may be supplemented with other treatment strategies depending on the severity. Based on the clinical outcome of these events, individualized treatment with locally available standard of care should be considered for the underlying nAMD. Conclusions These recommendations emphasize the need for early diagnosis, prompt and timely intervention, intensive treatment, and frequent monitoring to minimize the risk of progression of these events. The proposed recommendations may facilitate a consistent management approach of this spectrum of ocular inflammatory events should they arise in nAMD after treatment with brolucizumab or other anti-VEGFs. |
| Databáze: | OpenAIRE |
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