Retrospective multicenter study of allogeneic peripheral blood stem cell transplantation followed by reduced-intensity conditioning or conventional myeloablative regimen
| Autor: | Jong Gwang Kim, Sang Kyun Sohn, Je Joong Lee, Dong Hwan Kim, Seong-Jun Choi, Mark Hong Lee, Woo Sung Min, Jin Ho Baek, Je-Hwan Lee, Kyoo-Hyung Lee, Jong Wook Lee, Hyeoung Joon Kim, Dong-Wook Kim, Chun Choo Kim, Kyu Bo Lee |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning Adolescent Graft vs Host Disease Recurrence Medicine Humans Retrospective Studies business.industry Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology General Medicine Middle Aged Prognosis Survival Analysis humanities Peripheral blood Surgery Transplantation Regimen Multicenter study Reduced Intensity Conditioning Hematologic Neoplasms Immunology Peripheral Blood Stem Cell Transplantation Female Stem cell business human activities |
| Zdroj: | Acta haematologica. 113(4) |
| ISSN: | 0001-5792 |
| Popis: | This retrospective study compared the results of reduced-intensity conditioning stem cell transplantation (RIST) and a conventional myeloablative regimen (CST) followed by allogeneic peripheral blood stem cell transplantation. In this respect, 63 RISTs and 41 CSTs were performed at 5 transplantation centers in Korea between April 1998 and December 2002. The RIST group had more adverse pretransplant characteristics. More aggressive diseases, like acute myeloid or lymphoblastic leukemia, were included in the CST group, while the RIST group included more indolent diseases, like chronic myeloid leukemia or myeloma (p < 0.001). The incidence of acute graft-versus-host disease (GVHD) grades 2–4 was 29.1 and 57.9% for the RIST and CST groups, respectively (p = 0.010), yet the incidence of chronic GVHD was similar in the two groups (57.4 vs. 71.9%). With a median follow-up of 13 months (0.5–61 months, 17 months in 52 survivors), the 3-year overall (OS) and disease-free survival (DFS) was similar in the RIST and CST groups (p = 0.965 for OS, p = 0.545 for DFS). In a multivariate analysis, RIST (p = 0.010), good performance status (p = 0.006) and a higher CD34+ cell dose (p = 0.008) were all identified as independent favorable prognostic factors for OS. Accordingly, in the current study, RIST produced equivalent or acceptable results compared with CST in terms of OS. Therefore, a prospective randomized trial of RIST and CST is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|