Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI
| Autor: | Mustafa Sher, David Oehme, Julian A. Smith, Chris D. Daly, Ronil V. Chandra, Peter Ghosh, Tony Goldschlager, Idrees Sher |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Biometry Intervertebral Disc Degeneration Degenerative disc disease 03 medical and health sciences 0302 clinical medicine Medicine Animals Orthopedics and Sports Medicine Intervertebral Disc Reliability (statistics) 030222 orthopedics Lumbar Vertebrae Sheep medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging Intervertebral disc medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Disc degeneration Female Neurology (clinical) Radiology business 030217 neurology & neurosurgery Intervertebral Disc Displacement |
| Zdroj: | Spine. 44(13) |
| ISSN: | 1528-1159 |
| Popis: | Reliability study.To evaluate the applicability and reliability of 9.4T magnetic resonance imaging (MRI) in the assessment of degenerative disc disease compared with 3T MRI.MRI is a reliable indicator of biochemical changes in the intervertebral disc (IVD) including hydration status, proteoglycan content, and disc degeneration compared with anatomical and histological studies. High-field 9.4T MRI has been shown to provide superior resolution and anatomical detail. However, it has not been tested against current standard MRI techniques.Disc degeneration was initiated in 36 skeletally mature ewes 6 months prior to necropsy via validated surgical IVD injury models using either scalpel injury or drill-bit injury techniques at lumbar spine levels L2/3 and L3/4 with L1/2, L4/5, and L5/6 serving as control discs. All ex vivo IVDs were examined with 9.4T MRI and 3T MRI. All scans were analyzed using the Pfirrmann grading system by four independent observers. Intra- and interobserver reliability was assessed using kappa statistics and Spearman correlation.Inter- and intraobserver agreement for 9.4T MRI was excellent, both at κ 0.91 (P 0.001). Comparatively, 3T interobserver reliability demonstrated substantial agreement at κ 0.61 (P 0.001). Complete agreement was obtained in 92.7% to 100% of discs at 9.4T compared with 69.7% to 83.1% at 3T. A difference of one grade or more occurred in 6.7% at 9.4T and 39.3% at 3T. 9.4T MRI scored 97.3% of discs as grade 1 to 2 compared with 71.3% at 3T. 3T MRI tended to over-score the extent of disc degeneration with 28.6% of discs scored as grade 3 or higher compared with 2.7% at 9.4T MRI.9.4T MRI study of IVD degeneration using the Pfirrmann grading system demonstrated excellent inter- and intraobserver reliability. Comparatively, 3T MRI demonstrated a tendency to over score the extent of disc degeneration. This improved reliability of 9.4T MRI holds great potential for its clinical applications.3. |
| Databáze: | OpenAIRE |
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