Left ventricular systolic dysfunction is associated with poor functional outcomes after endovascular thrombectomy
| Autor: | Aloysius St Leow, Sageet Amlani, Tommy B. Andersson, Robert Michael, Hock-Luen Teoh, Ken Wong, Jens Maybaum, Nuran Abdullayev, Daniel Campbell, Tsong-Hai Lee, Vamsi Gontu, Oliver Spooner, Gopinathan Anil, Leonard L.L. Yeo, Raymond C.S. Seet, Prakash R Paliwal, Joshua Yeo, Anastasios Mpotsaris, Vivek Sharma, Bernard P.L. Chan, Ulf Quäschling, Pervinder Bhogal, Zhi-Xuan Ng, Chih-Kuang Cheng, Ching-Hui Sia, Stefan Schob, Staffan Holmin, Cunli Yang, Volker Maus, Chuan-Min Lin, Benjamin Yong-Qiang Tan, Hegoda Levansri Dilrukshan Makalanda, Ho-Fai Wong, Nicholas Jh Ngiam |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 030204 cardiovascular system & hematology Brain Ischemia Cohort Studies 03 medical and health sciences Cerebral circulation Ventricular Dysfunction Left 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Hospital Mortality Stroke Aged Retrospective Studies Thrombectomy Aged 80 and over Ejection fraction Cerebral infarction business.industry Endovascular Procedures Retrospective cohort study General Medicine Middle Aged medicine.disease Treatment Outcome Cerebral blood flow Cerebrovascular Circulation Cardiology Surgery Neurology (clinical) business Perfusion 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurointerventional surgery. 13(6) |
| ISSN: | 1759-8486 |
| Popis: | BackgroundEndovascular thrombectomy (ET) has transformed acute ischemic stroke (AIS) therapy in patients with large vessel occlusion (LVO). Left ventricular systolic dysfunction (LVSD) decreases global cerebral blood flow and predisposes to hypoperfusion. We evaluated the relationship between LVSD, as measured by LV ejection fraction (LVEF), and clinical outcomes in patients with anterior cerebral circulation LVO who underwent ET.MethodsThis multicenter retrospective cohort study examined anterior circulation LVO AIS patients from six international stroke centers. LVSD was measured by assessment of the echocardiographic LVEF using Simpson’s biplane method of discs according to international guidelines. LVSD was defined as LVEF ResultsWe included 440 AIS patients with LVO who underwent ET. On multivariate analyses, pre-existing diabetes mellitus (OR 2.05, 95% CI 1.24 to 3.39;p=0.005), unsuccessful reperfusion (Treatment in Cerebral Infarction (TICI) grade 0-2a) status (OR 4.21, 95% CI 2.04 to 8.66; pConclusionAnterior circulation LVO AIS patients with LVSD have poorer outcomes after ET, suggesting the need to consider cardiac factors for ET, the degree of monitoring and prognostication post-procedure. |
| Databáze: | OpenAIRE |
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