Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations
| Autor: | Pongvongsa Tiengkham, Samlane Phompida, Mayfong Mayxay, Rattanaxay Phetsouvanh, Nicholas J. White, Alan Brockman, Paul N. Newton, Maniphono Khanthavong |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Health Planning Guidelines Sulfadoxine medicine.medical_treatment Drug Resistance Drug resistance Antimalarials Chloroquine Internal medicine medicine Animals Humans Treatment Failure Malaria Falciparum biology business.industry Plasmodium falciparum biology.organism_classification medicine.disease Sulfadoxine/pyrimethamine Confidence interval Surgery Drug Combinations Pyrimethamine Treatment Outcome Infectious Diseases Laos Female business Malaria medicine.drug |
| Popis: | The in vivo efficacies of the Lao People's Democratic Republic (Laos) nationally recommended antimalarial agents--chloroquine and sulfadoxine-pyrimethamine-were assessed in a randomized, comparative trial that involved 100 patients with uncomplicated Plasmodium falciparum malaria who were followed for 42 days after starting treatment. Despite a shorter mean time to fever clearance associated with administration of chloroquine (mean time to clearance, 35.6 h; 95% confidence interval [CI], 26.3-45.0 h), compared with that associated with sulfadoxine-pyrimethamine (61.1 h; 95% CI, 50.9-71.3 h; P |
| Databáze: | OpenAIRE |
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