Acute and fulminant hepatitis induced by flutamide: case series report and review of the literature
| Autor: | Rodrigo Zapata, Javier Brahm, Erwin Buckel, Ricardo Latorre, Magdalena Brahm, Roberto Segovia, Luis Contreras, Jaime Poniachik |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Liver toxicity medicine.medical_treatment Specialties of internal medicine Liver transplantation Gastroenterology Risk Assessment Flutamide Hepatitis chemistry.chemical_compound Prostate cancer Young Adult Sex Factors Risk Factors Internal medicine medicine Humans Fulminant hepatitis Liver transplant Acne hirsutism Aged Retrospective Studies Liver injury Aged 80 and over Hepatology business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine medicine.disease Surgery Liver Transplantation Treatment Outcome chemistry RC581-951 Liver Acute Disease Female Chemical and Drug Induced Liver Injury business |
| Zdroj: | Annals of Hepatology, Vol 10, Iss 1, Pp 93-98 (2011) |
| ISSN: | 1665-2681 |
| Popis: | Flutamide is a non-steroidal anti-androgenic drug, commonly used in the treatment of advanced prostate cancer, acne and hirsutism. This drug may induce various degrees of liver injury, including acute liver failure (ALF), with further need for liver transplantation. Here, we present a report of 10 consecutive patients seen in a period of 14 years, with acute liver toxicity induced by flutamide (in most cases severe hepatotoxicity): 3 men and 7 women, with a mean age of 75 and 29 years old, respectively. All men received flutamide as treatment of advanced prostate carcinoma and they developed hepatotoxicity without ALF, and three months after withdrawal of the drug, they recovered completely. In contrast, in 7 young female with liver toxicity caused by flutamide as treatment of various hyperandrogenic conditions (acne and hirsutism), ALF was observed in 5 patients, all of them requiring urgent liver transplantation, with excellent outcome and survival in 4 of them. Based on the above, we believe that flutamide treatment should be preferentially avoided in young female patients with benign pathologies, or if it is used, patients should be warned of its potential severe complications. Also, serial liver tests should be closely monitored and, in case of elevations, the drug should be immediately withdrawn. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|