Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy:a clinical trial for oral hygiene and oral condition
| Autor: | Takeshi Nishino, Satomi Moriyama, Masami Yoshioka, Daisuke Hinode, Yuka Sogawa, Daniel Grenier, Akira Tangoku |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Rhus Kampo medicine.medical_treatment Antineoplastic Agents Oral hygiene Gastroenterology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine Mucositis Humans Medicine Glycyrrhiza uralensis Aged Stomatitis Chemotherapy Fusobacterium nucleatum biology Plant Extracts business.industry Campylobacter rectus 030206 dentistry General Medicine Middle Aged Esophageal cancer Oral Hygiene medicine.disease biology.organism_classification Gingivitis Bacterial Load Clinical trial stomatognathic diseases 030220 oncology & carcinogenesis Female Medicine Kampo Periodontal Index business Drugs Chinese Herbal |
| Zdroj: | The Journal of Medical Investigation. 65:184-190 |
| ISSN: | 1349-6867 1343-1420 |
| Popis: | Objective : The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Methods : Twenty-three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups : 7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. Results : No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the controlgroup (p |
| Databáze: | OpenAIRE |
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