Apathy, not depressive symptoms, as a predictor of semantic and phonemic fluency task performance in stroke and transient ischemic attack
| Autor: | Keera N. Fishman, Demetrios J. Sahlas, Krista L. Lanctôt, Megan L Cayley, Andrea R. Ashbaugh, Nathan Herrmann, Richard H. Swartz, Karen Lien, Michelle N. Sicard, Brian J. Murray |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Apathy Neuropsychological Tests 050105 experimental psychology Developmental psychology Young Adult 03 medical and health sciences Fluency 0302 clinical medicine Predictive Value of Tests medicine Humans 0501 psychology and cognitive sciences Young adult Stroke Depression (differential diagnoses) Aged Aged 80 and over Depression Verbal Behavior 05 social sciences Neuropsychology Reproducibility of Results Cognition Middle Aged Center for Epidemiologic Studies Depression Scale medicine.disease Semantics Clinical Psychology Cross-Sectional Studies Neuropsychology and Physiological Psychology Neurology Ischemic Attack Transient Female Neurology (clinical) medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Clinical and Experimental Neuropsychology. 40:449-461 |
| ISSN: | 1744-411X 1380-3395 |
| DOI: | 10.1080/13803395.2017.1371282 |
| Popis: | This study examined the relationship between apathy and cognition in patients with cerebrovascular disease. Apathy may result from damage to frontal subcortical circuits causing dysexecutive syndromes, but apathy is also related to depression. We assessed the ability of apathy to predict phonemic fluency and semantic fluency performance after controlling for depressive symptoms in 282 individuals with stroke and/or transient ischemic attack.Participants (N = 282) completed the Phonemic Fluency Test, Semantic Fluency Test, Center for Epidemiologic Studies Depression Scale, and Apathy Evaluation Scale. A cross-sectional correlational design was utilized.Using hierarchical linear regressions, apathy scores significantly predicted semantic fluency performance (β = -.159, p = .020), but not phonemic fluency performance (β = -.112, p = .129) after scaling scores by age and years of education and controlling for depressive symptoms. Depressive symptoms entered into the first step of both hierarchical linear regressions did not predict semantic fluency (β = -.035, p = .554) or phonemic fluency (β = -.081, p = .173). Apathy and depressive symptoms were moderately correlated, r(280) = .58, p .001.The results of this study are consistent with research supporting a differentiation between phonemic and semantic fluency tasks, whereby phonemic fluency tasks primarily involve frontal regions, and semantic fluency tasks involve recruitment of more extended networks. The results also highlight a distinction between apathy and depressive symptoms and suggest that apathy may be a more reliable predictor of cognitive deficits than measures of mood in individuals with cerebrovascular disease. Apathy may also be more related to cognition due to overlapping motivational and cognitive frontal subcortical circuitry. Future research should explore whether treatments for apathy could be a novel target for improving cognitive outcomes after stroke. |
| Databáze: | OpenAIRE |
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